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Key Properties for the Toxicity Classification of Chemicals: A Comparison of the REACH Regulation and Scientific Studies Trends

In the last half century, the improvements in quality of life owing to the development of the chemical industry are indisputable. However, despite global improvements, there has also been a large increase in pollution at the environmental level and this has caused relevant harmful risks not only to wildlife and the environment but also to human health. In response, governments have begun to regulate and control chemicals to prevent environmental pollution. At the European level, REACH (R...

The effects of thymoquinone on pancreatic cancer: Evidence from preclinical studies

Thymoquinone (TQ) is a secondary metabolite found in abundance in very few plant species including Nigella sativa L., Monarda fistulosa L., Thymus vulgaris L. and Satureja montana L. Preclinical pharmacological studies have shown that TQ has many biological activities, such as anti-inflammatory, antioxidant and anticancer. Both in vivo and in vitro experiments have shown that TQ acts as an antitumor agent by altering cell cycle progression, inhibiting cell proliferation, stimulating apoptosis...

Acute efects of a 60‑min time trial on power‑related parameters in trained endurance runners

Background: The advent of power meters for running has raised the interest of athletes and coaches in new ways of assessing changes in running performance. The aim of this study is to determine the changes in power-related variables during and after a strenuous endurance running time trial. Methods: Twenty-one healthy male endurance runners, with a personal record of 37.2 ± 1.2 min in a 10-km race, completed a 1-h run on a motorized treadmill trying to cover as much distance as they could. Be...

Neuroprotective Profile of Edible Flowers of Borage (Borago officinalis L.) in Two Different Models: Caenorhabditis elegans and Neuro-2a Cells

The flowers of Borago officinalis L. (Boraginaceae), commonly known as borage, are widely used as a culinary ingredient. The aim of this study was to assess the potential benefits of fresh borage flower extract related to antioxidant, neuroprotective and anti-aging properties. The extract was obtained by Soxhlet extraction with ethanol as a solvent, and fatty acids were detected by GC-FID. The antioxidant activity was evaluated in vitro through the DPPH, FRAP and ORAC assays. Regarding the fa...

Attack and Defense Performance in Goalball: A Proposal for Throwing, Balance and Acoustic Reaction Evaluation

Simple Summary Goalball is a dynamic sport for visually impaired people, where attack and defense situations alternate during the game. In attack situations, the throwing performance could be dependent on several variables such as the anthropometry, the core stability, or the balance of the athletes. In defense situations, the reaction time to an acoustic stimulus could be also considered as a performance factor. All these variables have been analyzed in this pilot study assessing the ball ve...