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dc.contributor.authorSanna, Maria Domenica-
dc.contributor.authorLes Parellada, Francisco-
dc.contributor.authorLópez Ramos, Víctor-
dc.contributor.authorGaleotti, Nicoletta-
dc.date.accessioned2019-12-11T10:51:33Z-
dc.date.available2019-12-11T10:51:33Z-
dc.date.issued2019-05-09-
dc.identifier.citationSanna MD, Les F, Lopez V and Galeotti N (2019) Lavender (Lavandula angustifolia Mill.) Essential Oil Alleviates Neuropathic Pain in Mice With Spared Nerve Injury. Front. Pharmacol. 10:472. doi: 10.3389/fphar.2019.00472es_ES
dc.identifier.issn2314-6141es_ES
dc.identifier.urihttps://repositorio.usj.es/handle/123456789/258-
dc.description.abstractLow treatment efficacy represents an important unmet need in neuropathic pain patients and there is an urgent need to develop a more effective pharmacotherapy. An increasing number of patients choose complementary medicine to relieve pain. Lavender essential oil (LEO) is approved by the European Medicines Agency as herbal medicine to relieve anxiety and stress. However, the capability of LEO to relieve other nervous system disorders such as neuropathic pain has never been established. Our work aimed to evaluate the antineuropathic properties of lavender on a spared nerve injury (SNI) model of neuropathic pain in mice. An acute oral administration of LEO (100 mg/kg) alleviated SNI-induced mechanical allodynia, evaluated in the von Frey test, with an intensity comparable to the reference drug pregabalin. Investigations into the mechanism of action showed that LEO markedly decreased the phosphorylation of ERK1, ERK2, and JNK1, and decreased the levels of iNOS in the spinal cord; involvement of the endocannabinoid system was also detected using in vitro inhibition of the FAAH and MALG enzymes as well as in vivo experiments with the CB1 antagonist. Conversely, no effect on P38 phosphorylation and NF-kB activation was detected. These antihyperalgesic effects appeared at the same dose able to induce antidepressant-like, anxiolytic-like, and anorexic effects. In addition, gavage with LEO did not significantly alter animals’ gross behavior, motor coordination, or locomotor activity, nor impaired memory functions. Oral administration of LEO could represent a therapeutic approach in the management of neuropathic pain states.es_ES
dc.format.extent13 p.es_ES
dc.format.mimetypeapplication/pdfes_ES
dc.language.isoenges_ES
dc.publisherAnna Karolina Kiss, Medical University of Warsaw, Polandes_ES
dc.relation.requiresAdobe PDFes_ES
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectLavender essential oiles_ES
dc.subjectCentral nervous systemes_ES
dc.subjectNeuropathic paines_ES
dc.subjectAnxietyes_ES
dc.subjectDepressiones_ES
dc.subjectMemoryes_ES
dc.subjectFeedingses_ES
dc.titleLavender (Lavandula angustifolia Mill.) Essential Oil Alleviates Neuropathic Pain in Mice With Spared Nerve Injuryes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.subject.unescoAceite vegetales_ES
dc.subject.unescoEnfermedad del sistema nerviosoes_ES
dc.relation.publisherversionhttps://www.frontiersin.org/articles/10.3389/fphar.2019.00472/fulles_ES
dc.identifier.doi10.3389/fphar.2019.00472es_ES
dc.rights.accessrightsinfo:eu-repo/semantics/openAccesses_ES
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