Please use this identifier to cite or link to this item: https://repositorio.usj.es/handle/123456789/287

Title: Acute lethal and sublethal effects of diltiazem and doxepin for four aquatic environmental bioindicators covering the trophic chain
Authors: Ros, Natalia
Lomba Eraso, Laura ORCID RESEARCHERID SCOPUSID
Ribate Molina, Mª Pilar SCOPUSID
Zuriaga Marco, Estefanía ORCID
García García, Cristina Belén ORCID RESEARCHERID SCOPUSID
Giner Parache, Beatriz SCOPUSID
Keywords: Doxepin; Diltiazem; EC50; Environmental risk assessment; Ecotoxicity
Issue Date: 24-Jul-2018
Publisher: AMER INST MATHEMATICAL SCIENCES-AIMS, PO BOX 2604, SPRINGFIELD, MO 65801-2604 USA
Citation: Laura Lomba, M. Pilar Ribate, Estefanía Zuriaga, Cristina B. García, Beatriz Giner, Acute and subacute effects of drugs in embryos of Danio rerio. QSAR grouping and modelling, Ecotoxicology and Environmental Safety, 2019, 172, 232, 10.1016/j.ecoenv.2019.01.081
Abstract: Pharmaceuticals are becoming an environmental and health problem of concern. We present here the results obtained in the ecotoxicological evaluation of two drugs (diltiazem and doxepin) recurrently present in the environment. To carry out this study, four aquatic bioindicators (Vibrio fischeri, Daphnia magna, Selenastrum capricornutum, and Danio rerio) were used and the lethal, sublethal and/or inhibition effects were obtained. Furthermore, in order to complete environmental information, several key physicochemical properties were also measured (solubility, critical aggregation concentration and partition coefficient). High solubility for doxepin seems to be related with its bioavailability and thus, lead to higher toxicity. However, EC50 ecotoxocity values for doxepin and diltiazem are between 100 and 1000 mg/L for all the studied environmental bioindicators, and thus, none of the drugs should be considered as potentially harmful for the environment.
URI: https://repositorio.usj.es/handle/123456789/287
ISSN: 2372-0352
Appears in Collections:Artículos de revistas

Files in This Item:
File Description SizeFormat 
s12889-018-6070-9.pdf826,2 kBAdobe PDFThumbnail
View/Open


This item is licensed under a Creative Commons License Creative Commons