Please use this identifier to cite or link to this item: https://repositorio.usj.es/handle/123456789/287

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dc.contributor.authorRos, Natalia-
dc.contributor.authorLomba Eraso, Laura-
dc.contributor.authorRibate Molina, Mª Pilar-
dc.contributor.authorZuriaga Marco, Estefanía-
dc.contributor.authorGarcía García, Cristina Belén-
dc.contributor.authorGiner Parache, Beatriz-
dc.date.accessioned2020-01-14T10:51:59Z-
dc.date.available2020-01-14T10:51:59Z-
dc.date.issued2018-07-24-
dc.identifier.citationLaura Lomba, M. Pilar Ribate, Estefanía Zuriaga, Cristina B. García, Beatriz Giner, Acute and subacute effects of drugs in embryos of Danio rerio. QSAR grouping and modelling, Ecotoxicology and Environmental Safety, 2019, 172, 232, 10.1016/j.ecoenv.2019.01.081es_ES
dc.identifier.issn2372-0352es_ES
dc.identifier.urihttps://repositorio.usj.es/handle/123456789/287-
dc.description.abstractPharmaceuticals are becoming an environmental and health problem of concern. We present here the results obtained in the ecotoxicological evaluation of two drugs (diltiazem and doxepin) recurrently present in the environment. To carry out this study, four aquatic bioindicators (Vibrio fischeri, Daphnia magna, Selenastrum capricornutum, and Danio rerio) were used and the lethal, sublethal and/or inhibition effects were obtained. Furthermore, in order to complete environmental information, several key physicochemical properties were also measured (solubility, critical aggregation concentration and partition coefficient). High solubility for doxepin seems to be related with its bioavailability and thus, lead to higher toxicity. However, EC50 ecotoxocity values for doxepin and diltiazem are between 100 and 1000 mg/L for all the studied environmental bioindicators, and thus, none of the drugs should be considered as potentially harmful for the environment.es_ES
dc.format.extent15 p.es_ES
dc.format.mimetypeapplication/pdfes_ES
dc.language.isoenges_ES
dc.publisherAMER INST MATHEMATICAL SCIENCES-AIMS, PO BOX 2604, SPRINGFIELD, MO 65801-2604 USAes_ES
dc.relationGREENLIFE (E105) acknowledges financial support from Gobierno de Aragon and Fondo Social Europeo "Construyendo Europa desde Aragon". Furthermore, GREENLIFE acknowledges financial support from Ministerio de Economia y Competitividad (CTQ2013-44867-P) and FEDER. Finally, GREENLIFE thanks EEE53 SL. Business groups: Pinares de Venecia Division Energetica and Brial (ENATICA) for support. Both business groups are committed to sustainable developments through environmental respect.es_ES
dc.relation.requiresAdobe PDFes_ES
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectDoxepines_ES
dc.subjectDiltiazemes_ES
dc.subjectEC50es_ES
dc.subjectEnvironmental risk assessmentes_ES
dc.subjectEcotoxicityes_ES
dc.titleAcute lethal and sublethal effects of diltiazem and doxepin for four aquatic environmental bioindicators covering the trophic chaines_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.subject.unescoMedio ambientees_ES
dc.subject.unescoEvaluación del impacto ambientales_ES
dc.relation.publisherversionhttps://www.aimspress.com/article/10.3934/environsci.2018.4.229es_ES
dc.identifier.doi10.3934/environsci.2018.4.229.es_ES
dc.rights.accessrightsinfo:eu-repo/semantics/openAccesses_ES
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