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dc.contributor.authorLes Parellada, Francisco-
dc.contributor.authorIffiú-Soltész, Zsuzsa-
dc.contributor.authorMercarder, Josep-
dc.contributor.authorCarpene, Christian-
dc.date.accessioned2020-04-21T14:15:40Z-
dc.date.available2020-04-21T14:15:40Z-
dc.date.issued2017-
dc.identifier.citationFrancisco Les, Zsuzsa Iffiú-Soltész, Josep Mercarder, Christian Carpéné. Tyramine activates lipid accumulation in rat adipocytes: influences of in vitro and in vivo administration. AIMS Molecular Science, 2017, 4(3): 339-351. doi: 10.3934/molsci.2017.3.339es_ES
dc.identifier.issn2372-0301es_ES
dc.identifier.urihttps://repositorio.usj.es/handle/123456789/375-
dc.description.abstractTyramine is naturally occurring in foods. This biogenic amine is known to induce hypertension, especially when ingested by individuals treated by irreversible inhibitors of monoamine oxidases (MAO). However, in animals, tyramine is also an agonist for trace amine-associated receptors and substrate of semicarbazide-sensitive amine oxidases (SSAO). Though tyramine can alter aminergic transmission by various mechanisms, it was recently reported that prolonged tyramine supplementation does not deteriorate glucose tolerance and does not cause adverse cardiovascular effects in mice. Since previous studies have described insulin-like effects of tyramine in fat cells from diabetic rats, we have further tested tyramine in vitro and in vivo actions on fattening. To this aim, antilipolytic and lipogenic responses to insulin and tyramine were first compared in rat adipocytes while tyramine oxidation was compared in adipose and intestinal tissues. Then, effects of repeated intraperitoneal injections of tyramine (17 [tmol/kg/day) on adiposity and on adipocyte functions were studied in young and mature rats. Millimolar doses of tyramine inhibited glycerol release by adipocytes with a maximal antilipolytic effect comparable to that of insulin. Repeated tyramine administration enhanced fat deposition in epididymal white adipose tissue, irrespective of the age of treated rats. This effect was not accompanied by desensitization to lipogenic activation by insulin, tyramine or hydrogen peroxide. Lastly, tyramine was more readily oxidized in adipose than in intestinal tissues when enzymatic activity was expressed per mg of protein. Moreoever, MAO mostly contributed to oxidative deamination in gut while SSAO was predominant in fat. Thus, both short-term and prolonged effects of tyramine were evidencing somewhat insulin-like actions in adipose tissue and led to reconsider the risk/benefit ratio of the dietary intake of this amine.es_ES
dc.format.extent13 p.es_ES
dc.format.mimetypeapplication/pdfes_ES
dc.language.isoenges_ES
dc.publisherAMER INST MATHEMATICAL SCIENCES-AIMS, PO BOX 2604, SPRINGFIELD, MO 65801-2604 USAes_ES
dc.relationThis study was partly supported by recurrent grant from INSERM to Unit 1048. The authors express gratitude to the staff of PA3S (Pole Aliment Sante Securite Sanitaire, Toulouse, France) for facilitating scientific debates on the role of amines as micronutrients. Authors also thank Sandy Bour and Danielle Prevot for participating in preliminary observations. In memory of Michel Berlan, our missing master who was a pioneer specialist of biogenic amines and fat storage.es_ES
dc.relation.requiresAdobe PDFes_ES
dc.rightsAtribución-NoComercial 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.subjectAdipocyteses_ES
dc.subjectMonoamine oxidasees_ES
dc.subjectSemicarbazide-sensitive amine oxidasees_ES
dc.subjectObesityes_ES
dc.subjectGlucose homeostasises_ES
dc.subjectVanadiumes_ES
dc.subjectGlyceroles_ES
dc.titleTyramine activates lipid accumulation in rat adipocyteses_ES
dc.typejournal articlees_ES
dc.subject.unescoObesidades_ES
dc.relation.publisherversionhttps://www.aimspress.com/article/10.3934/molsci.2017.3.339es_ES
dc.identifier.publicationfirstpage339es_ES
dc.identifier.publicationlastpage351es_ES
dc.identifier.doi10.3934/molsci.2017.3.339es_ES
dc.rights.accessRightsopen accesses_ES
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