Please use this identifier to cite or link to this item:

Title: Phytochemicals and enzyme inhibitory capacities of the methanolic extracts from the italian apple cultivar mela rosa dei monti sibillini
Authors: López Ramos, Víctor ORCID SCOPUSID
Les Parellada, Francisco ORCID SCOPUSID
Mevi, Serena SCOPUSID
Wandjou, Joice Guileine Nkuimi SCOPUSID
Cásedas, Guillermo ORCID SCOPUSID
Maggi, Filippo ORCID
Keywords: Apple Peels; Phlorizin; Malus; Polyphenols; Triterpenes; Antioxidants; Enzyme inhibitors; Apple; Functional foods
Issue Date: 22-Jun-2020
Publisher: MDPI AG
Citation: López, Víctor et al. "Phytochemicals and Enzyme Inhibitory Capacities of the Methanolic Extracts from the Italian Apple Cultivar Mela Rosa dei Monti Sibillini." Pharmaceuticals (Basel, Switzerland) vol. 13,6 127. 22 Jun. 2020, doi:10.3390/ph13060127
Abstract: The phytochemical profile of the methanolic extracts (pulp and peel) obtained from two dehydration methods (drying and freeze-lyophilization) of the traditional Italian apple Mela Rosa dei Monti Sibillini, as well as their inhibitory properties against some biological enzymes (α-glucosidase, lipase, monoamine oxidase A, tyrosinase and acetylcholinesterase) were assessed in this study. HPLC-DAD-MS technique was used for the determination of polyphenolic and triterpenic compounds. The determination of the enzymes inhibitory effect was made through spectrophotometric techniques. The peel extracts were richer in bioactive compounds than the pulp. In this regard, the extracts from freeze-lyophilization displayed higher levels of flavan-3-ols, flavonol glycosides and dihydrochalcones. However, the extracts obtained from dried material displayed a stronger enzyme inhibition. Notably, the peel extracts showed a higher activity than the pulp ones, especially in terms of α-glucosidase whereby some samples exerted a similar enzymatic inhibition than acarbose (100% inhibition) at high concentrations (1 mg/mL). These results encourage thus further studies on this traditional Italian apple as a potential source of nutraceuticals helpful to prevent the insurgence of some pathologies. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
ISSN: 1424-8247
Appears in Collections:Artículos de revistas

Files in This Item:
File Description SizeFormat 
Phytochemicals and Enzyme Inhibitory Capacities.pdf1,41 MBAdobe PDFThumbnail

This item is licensed under a Creative Commons License Creative Commons