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Título : Cytotoxic, antioxidant, and enzyme inhibitory properties of the traditional medicinal plant matthiola incana
Autor: Taviano, Maria Fernanda ORCID SCOPUSID
Miceli, Natalizia ORCID RESEARCHERID SCOPUSID
Acquaviva, Rosaria ORCID RESEARCHERID SCOPUSID
Antonio Malfa, Giuseppe ORCID RESEARCHERID SCOPUSID
Ragusa, Salvatore ORCID RESEARCHERID SCOPUSID
Giordano, Deborah SCOPUSID
Cásedas, Guillermo ORCID SCOPUSID
Les Parellada, Francisco ORCID SCOPUSID
López Ramos, Víctor ORCID SCOPUSID
Palabras clave : Anti-glucosidasa; Antioxidante; Plantas medicinales; inhibidor de la enzima; Polifenoles; Flor común; Brassicacea
Fecha de publicación: 13-jul-2020
Editorial : MDPI
Citación : aviano, M.F., Miceli, N., Acquaviva, R., Malfa, G.A., Ragusa, S., Giordano, D., Cásedas, G., Les, F., López, V., 2020. Cytotoxic, Antioxidant, and Enzyme Inhibitory Properties of the Traditional Medicinal Plant Matthiola incana (L.) R. Br.. Biology 9, 163.. doi:10.3390/biology9070163
Resumen : Matthiola incana(L.) R. Br. (Brassicaceae) is widely cultivated for ornamental purposes andutilized as a medicinal plant. In the present work, the hydroalcoholic extract from the aerial parts ofthis species has been evaluated in different bioassays in order to detect potential pharmacologicalapplications.The cytotoxic capacity against the human colorectal adenocarcinoma (CaCo-2)and breast cancer (MCF-7) cell lines was tested using the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. The extract was investigated as a neuroprotective inhibitor ofcentral nervous system (CNS) enzymes such as monoamine oxidase A, tyrosinase, acetylcholinesterase,and as a natural enzyme inhibitor ofα-glucosidase and lipase involved in some metabolic disorderssuch as obesity or type 2 diabetes. The antioxidant ability was also evaluated in an enzymatic system(xanthine/xanthine oxidase assay). Results showed that theM. incanaextract displayed moderate tolow cytotoxicity vs. CaCo-2 cells. The extract acted as a superoxide radical scavenger and enzymaticinhibitor of monoamine oxidase A, tyrosinase,α-glucosidase, and lipase. The best results werefound in theα-glucosidase assay, asM. incanahydroalcoholic extract was able to inhibit the enzymeα-glucosidase up to 100% without significant differences, compared to the antidiabetic drug acarbose.Matthiola incanahas been demonstrated to exert different biological properties. These are importantin order to consider this species as a source of bioactive compounds
URI : https://repositorio.usj.es/handle/123456789/451
ISSN : 2079-7737
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