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dc.contributor.authorMartín-Yebra, Alba-
dc.contributor.authorCaiani, Enrico G.-
dc.contributor.authorLaguna, Pablo-
dc.contributor.authorMonasterio, Violeta-
dc.contributor.authorPablo Martínez, Juan-
dc.identifier.citationA. Martín-Yebra, E. G. Caiani, P. Laguna, V. Monasterio and J. P. Martínez, "Circadian modulation on T-wave alternans activity in chronic heart failure patients," 2015 Computing in Cardiology Conference (CinC), Nice, France, 2015, pp. 845-848, doi: 10.1109/CIC.2015.7411043.es_ES
dc.description.abstractAverage TWA activity has been shown to be an independent predictor of sudden cardiac death (SCD) in chronic hean failure (CHF) patients% flowerer the influence o f cireadian rhythms on TWA remains understudied. In this work, we assessed circadian TWA changes in a CHF population and evaluated whether the prognostic value of TWA indices Ls sensitive to the circadian pattern. Hotter ECG recordings from 626 consecutive CHF patients (52 SCD) were analyzed. The index of average altemans (IAA), quantiffing the average TWA level, was measured in 4 consecutive 6-hour intervals using a multi lead fully-cuttomated method. Survival analysis vvas performed considering SCD as an independent endpoint. IAA changed along the day,. with statistically significtmt lower values during the night than during daytime. This patterrt is similar to the one observed in the mean heart rate (HR). However, a low correlation (r= 18) was found between MA and HR in windows of 128 heats. After dichototnizatthn f patients based on the third quartile of IAA indices, IAA indices computed between hours 06-12 (IAA,) and 18-24 (1AA,) successfully predicted SCD (Hazard Ratio, HaR.-2.34( 1.33-4.13) per IN, and HaR:1.87(1.04-3.36) per ktV, respectively). In conclusion, circadian variation should be considered for SCD risk prediction.es_ES
dc.relationThis work was supported by CIBER in Bioengineering, Biomaterials & Nanomedicne (CIBER-BBN) through Instituto de Salud Carlos III and FEDER (Spain), project TEC2013-42140-R funded by MINECO and FEDER, and by Gobierno de Arag ´on and European Social Fund (EU) through BSICoS Group (T96). The computation was performed by the ICTS NANBIOSIS, more specifically by the High Performance Computing Unit of the CIBER-BBN at the University of Zaragoza.es_ES
dc.relation.requiresAdobe PDFes_ES
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.subjectSudden Cardiac Deathes_ES
dc.subjectRisk Stratificationes_ES
dc.titleCircadian Modulation on T-wave Alternans Activity in Chronic Heart Failure Patientses_ES
dc.identifier.publicationtitleComputing in Cardiology 2015 volume 42 : September 6-9, 2015, Nice, Francees_ES
dc.relation.eventplaceComp in Cardiol 2015, nice, FRANCEes_ES
dc.relation.eventtitle2015 Comp in Cardiol Conference (CinC)es_ES
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