Please use this identifier to cite or link to this item: https://repositorio.usj.es/handle/123456789/600

Title: Supercritical antisolvent fractionation of antioxidant compounds from salvia officinalis
Authors: Mur, Raquel SCOPUSID
Pardo, Juan Ignacio SCOPUSID
Pino Otín, Rosa ORCID SCOPUSID
Urieta, José Santiago ORCID SCOPUSID
Mainar, Ana M. ORCID RESEARCHERID SCOPUSID
Keywords: Advanced separation processes; Supercritical antisolvent fractionation; Rosmarinic acid; Caffeic acid; Chlorogenic acid; Antioxidant activity; QSAR
Issue Date: 28-Aug-2021
Publisher: MDPI AG
Citation: Mur, R.; Pardo, J.I.; Pino-Otín, M.R.; Urieta, J.S.; Mainar, A.M. Supercritical Antisolvent Fractionation of Antioxidant Compounds from Salvia officinalis. Int. J. Mol. Sci. 2021, 22, 9351. https:// doi.org/10.3390/ijms22179351
Abstract: The increasing interest towards greener antioxidants obtained via natural sources and more sustainable processes encourages the development of new theoretical and experimental methods in the field of those compounds. Two advanced separation methods using supercritical CO2 are applied to obtain valuable antioxidants from Salvia officinalis, and a first approximation to a QSAR model relating molecular structure with antioxidant activity is explored in order to be used, in the future, as a guide for the preselection of compounds of interest in these processes. Separation experiments through antisolvent fractionation with supercritical CO2 were designed using a Response Surface Methodology to study the effect of pressure and CO2 flow rate on both mass yields and capability to obtain fractions enriched in three antioxidant compounds: chlorogenic acid, caffeic acid and rosmarinic acid which were tracked using HPLC PDA. Rosmarinic acid was completely retained in the precipitation vessel while chlorogenic and caffeic acids, though distributed between the two separated fractions, had a major presence in the precipitation vessel too. The conditions predicted for an optimal overall yield and enrichment were 148 bar and 10 g/min. Although a training dataset including much more compounds than those now considered can be recommended, descriptors calculated from the σ-profiles provided by COSMO-RS model seem to be adequate for estimating the antioxidant activity of pure compounds through QSAR.
URI: https://repositorio.usj.es/handle/123456789/600
ISSN: 1661-6596
Appears in Collections:Artículos de revistas

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