Please use this identifier to cite or link to this item: https://repositorio.usj.es/handle/123456789/636

Title: Jasonia glutinosa (L.) DC., a Traditional Herbal Tea, Exerts Antioxidant and Neuroprotective Properties in Different In Vitro and In Vivo Systems
Authors: Les Parellada, Francisco ORCID SCOPUSID
Valero Gracia, Marta Sofía ORCID SCOPUSID
Moliner Langa, Ana Cristina ORCID SCOPUSID
Weinkove D. ORCID RESEARCHERID SCOPUSID
López Ramos, Víctor ORCID SCOPUSID
Gómez-Rincón, Carlota ORCID SCOPUSID
Keywords: Medicinal plants; C. elegans; Acetylcholinesterase; Monoamine oxidase A; Tyrosinase; Herbal medicine; Lifespan
Issue Date: 18-May-2021
Publisher: MDPI AG
Citation: Les, F.; Valero, M.S.; Moliner, C.; Weinkove, D.; López, V.; Gómez-Rincón, C. Jasonia glutinosa (L.) DC., a Traditional Herbal Tea, Exerts Antioxidant and Neuroprotective Properties in Different In Vitro and In Vivo Systems. Biology 2021, 10, 443. https:// doi.org/10.3390/biology10050443
Abstract: In traditional medicine, Jasonia glutinosa (L.) DC or rock tea (RT) has been mainly used to treat digestive and respiratory pathologies but also as an antimicrobial or an antidepressant herbal remedy. An ethanolic extract of RT has been demonstrated to have antioxidant and anti-inflammatory effects, which may be explained by its phytochemical profile, rich in polyphenols and pigments. The aim of this study is to investigate the neuroprotective potential of RT. For this purpose, the ethanolic extract of RT is assayed in Caenorhabditis elegans (C. elegans) as an in vivo model, and through in vitro assays using monoamine oxidase A, tyrosinase and acetylcholinesterase as enzymes. The RT extract reduces juglone-induced oxidative stress in worms and increases the lifespan and prevents paralysis of C. elegans CL4176, a model of Alzheimer’s disease; the extract is also able to inhibit enzymes such as acetylcholinesterase, monoamine oxidase A and tyrosinase in vitro. Together these results demonstrate that Jasonia glutinosa is a good candidate with antioxidant and neuroprotective potential for the development of new products with pharmaceutical interests.
URI: https://repositorio.usj.es/handle/123456789/636
ISSN: 2079-7737
Appears in Collections:Artículos de revistas



This item is licensed under a Creative Commons License Creative Commons