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Título : | Isofuranodiene, a Natural Sesquiterpene Isolated from Wild Celery (Smyrnium olusatrum L.), Protects Rats against Acute Ischemic Stroke |
Autor: | Yousefi-Manesh, Hasan
Dehpour, A. R. Shirooie, Samira Bagheri, Fariba Farrokhi, Vida Mousavi, Seyyedeh Elaheh Ricciutelli, Massimo Cappellacci, Loredana López Ramos, Víctor Maggi, Filippo Petrelli, Riccardo |
Palabras clave : | Isofuranodiene; Smyrnium olusatrum L.; Ischemic stroke; NF-kB; IL-1 beta; TNF-alpha |
Fecha de publicación: | 9-abr-2021 |
Editorial : | MDPI |
Citación : | Yousefi-Manesh, H.; Dehpour, A.R.; Shirooie, S.; Bagheri, F.; Farrokhi, V.; Mousavi, S.E.; Ricciutelli, M.; Cappellacci, L.; López, V.; Maggi, F.; et al. Isofuranodiene, a Natural Sesquiterpene Isolated from Wild Celery (Smyrnium olusatrum L.), Protects Rats against Acute Ischemic Stroke. Pharmaceuticals 2021, 14, 344. https://doi.org/10.3390/ph14040344 |
Resumen : | The myrrh-like furanosesquiterpene isofuranodiene (IFD) is the main constituent of wild celery (Smyrnium olusatrum L., Apiaceae), an overlooked vegetable that was cultivated during the Roman Empire. In the present study, we investigated the protective effects of IFD pre-treatment against oxidative stress and inflammatory response in an animal model of ischemic stroke. IFD was isolated by the crystallization of Smyrnium olusatrum essential oil, and its structure and purity were confirmed by NMR and HPLC analyses. Acute pre-treatment of IFD (10 mg/kg i.p.) significantly reduced the levels of the inflammatory cytokines IL-1 beta and TNF-alpha, the expression of pNF-kappa B/NF-kappa B, and the lipid peroxidation indicator MDA. Finally, IFD boosted a faster recovery and better scores in grid-walking and modified neurological severity scores (mNSS) tests. Taken together, these findings indicate IFD as a promising lead compound for the discovery of new treatments of brain ischemia. |
URI : | https://repositorio.usj.es/handle/123456789/637 |
ISSN : | 1424-8247 |
Aparece en las colecciones: | Artículos de revistas |
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