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Título : | The effects of thymoquinone on pancreatic cancer: Evidence from preclinical studies |
Autor: | Butnariu, Monica
Quispe, Cristina Herrera-Bravo, Jesús Helon, Paweł Kukula-Koch, Wirginia López Ramos, Víctor Les Parellada, Francisco Valdes Vergara, Cristian Alarcón-Zapata, Pedro Alarcón-Zapata, Barbara Martorell, Miquel Pentea, Marius Dragunescu, Aneta Anca Samfira, Ionel Yessimsiitova, Zura Dastan, Sevgi Durna Salgado Castillo, Carla Marina Roberts, Thomas H Sharifi-Rad, Javad Koch, Wojciech Cho, William Chi Shing |
Palabras clave : | Thymoquinone; Pancreatic cancer; Chemopreventive/anticancer agent; Apoptosis; Molecular mechanisms; Signaling pathways |
Fecha de publicación: | 8-jul-2022 |
Editorial : | Elsevier |
Citación : | Butnariu, M.; Quispe, C., Herrera-Bravo, J.; Helon P.; Kukula-Koch, V.; López, V.; Les, F.; Vald´es Vergara, C.; Alarc´on-Zapata, P.; Alarc´on-Zapata, B.; Martorell, M.; Pentea, M.; Dragunescu, A. A.; Samfira, I.; Yessimsiitova, Z.; Durna Das¸tan, S.; Marina Salgado Castillo, C.; Roberts, T. H.; Sharifi-Rad, J.; Koch, W.; Cho, W. C. The effects of thymoquinone on pancreatic cancer: Evidence from preclinical studies. Biomedicine & Pharmacotherapy 2022, 153, 113364. https://doi.org/10.1016/j.biopha.2022.113364 |
Resumen : | Thymoquinone (TQ) is a secondary metabolite found in abundance in very few plant species including Nigella sativa L., Monarda fistulosa L., Thymus vulgaris L. and Satureja montana L. Preclinical pharmacological studies have shown that TQ has many biological activities, such as anti-inflammatory, antioxidant and anticancer. Both in vivo and in vitro experiments have shown that TQ acts as an antitumor agent by altering cell cycle progression, inhibiting cell proliferation, stimulating apoptosis, inhibiting angiogenesis, reducing metastasis and affecting autophagy. In this comprehensive study, the evidence on the pharmacological potential of TQ on pancreatic cancer is reviewed. The positive results of preclinical studies support the view that TQ can be considered as an additional therapeutic agent against pancreatic cancer. The possibilities of success for this compound in human medicine should be further explored through clinical trials |
URI : | https://repositorio.usj.es/handle/123456789/873 |
ISSN : | 1950-6007 |
Aparece en las colecciones: | Artículos de revistas |
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The effects of thymoquinone on pancreatic cancer.pdf | 1,98 MB | Adobe PDF | Visualizar/Abrir |
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