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dc.contributor.authorButnariu, Monica-
dc.contributor.authorQuispe, Cristina-
dc.contributor.authorHerrera-Bravo, Jesús-
dc.contributor.authorHelon, Paweł-
dc.contributor.authorKukula-Koch, Wirginia-
dc.contributor.authorLópez Ramos, Víctor-
dc.contributor.authorLes Parellada, Francisco-
dc.contributor.authorValdes Vergara, Cristian-
dc.contributor.authorAlarcón-Zapata, Pedro-
dc.contributor.authorAlarcón-Zapata, Barbara-
dc.contributor.authorMartorell, Miquel-
dc.contributor.authorPentea, Marius-
dc.contributor.authorDragunescu, Aneta Anca-
dc.contributor.authorSamfira, Ionel-
dc.contributor.authorYessimsiitova, Zura-
dc.contributor.authorDastan, Sevgi Durna-
dc.contributor.authorSalgado Castillo, Carla Marina-
dc.contributor.authorRoberts, Thomas H-
dc.contributor.authorSharifi-Rad, Javad-
dc.contributor.authorKoch, Wojciech-
dc.contributor.authorCho, William Chi Shing-
dc.date.accessioned2022-12-05T13:06:34Z-
dc.date.available2022-12-05T13:06:34Z-
dc.date.issued2022-07-08-
dc.identifier.citationButnariu, M.; Quispe, C., Herrera-Bravo, J.; Helon P.; Kukula-Koch, V.; López, V.; Les, F.; Vald´es Vergara, C.; Alarc´on-Zapata, P.; Alarc´on-Zapata, B.; Martorell, M.; Pentea, M.; Dragunescu, A. A.; Samfira, I.; Yessimsiitova, Z.; Durna Das¸tan, S.; Marina Salgado Castillo, C.; Roberts, T. H.; Sharifi-Rad, J.; Koch, W.; Cho, W. C. The effects of thymoquinone on pancreatic cancer: Evidence from preclinical studies. Biomedicine & Pharmacotherapy 2022, 153, 113364. https://doi.org/10.1016/j.biopha.2022.113364en_US
dc.identifier.issn1950-6007en_US
dc.identifier.urihttps://repositorio.usj.es/handle/123456789/873-
dc.description.abstractThymoquinone (TQ) is a secondary metabolite found in abundance in very few plant species including Nigella sativa L., Monarda fistulosa L., Thymus vulgaris L. and Satureja montana L. Preclinical pharmacological studies have shown that TQ has many biological activities, such as anti-inflammatory, antioxidant and anticancer. Both in vivo and in vitro experiments have shown that TQ acts as an antitumor agent by altering cell cycle progression, inhibiting cell proliferation, stimulating apoptosis, inhibiting angiogenesis, reducing metastasis and affecting autophagy. In this comprehensive study, the evidence on the pharmacological potential of TQ on pancreatic cancer is reviewed. The positive results of preclinical studies support the view that TQ can be considered as an additional therapeutic agent against pancreatic cancer. The possibilities of success for this compound in human medicine should be further explored through clinical trialsen_US
dc.format.extent10 p.en_US
dc.format.mimetypeapplication/pdfen_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relationThis work was supported by ANID CENTROS BASALES ACE 210012. and Medical University of Lublin, grant number 07/2022en_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectThymoquinoneen_US
dc.subjectPancreatic canceren_US
dc.subjectChemopreventive/anticancer agenten_US
dc.subjectApoptosisen_US
dc.subjectMolecular mechanismsen_US
dc.subjectSignaling pathwaysen_US
dc.titleThe effects of thymoquinone on pancreatic cancer: Evidence from preclinical studiesen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.identifier.doihttps://doi.org/10.1016/j.biopha.2022.113364en_US
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessen_US
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