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dc.contributor.authorReigada, Inés-
dc.contributor.authorKapp, Karmen-
dc.contributor.authorMaynard, Claire-
dc.contributor.authorWeinkove, David-
dc.contributor.authorValero Gracia, Marta Sofía-
dc.contributor.authorLanga Morales, Elisa-
dc.contributor.authorHanski, Leena-
dc.contributor.authorGómez-Rincón, Carlota-
dc.identifier.citationReigada, I.; Kapp, K.; Maynard, C.;Weinkove, D.; Valero, M.S.; Langa, E.; Hanski, L.; Gómez-Rincón, C. Alterations in Bacterial Metabolism Contribute to the Lifespan Extension Exerted by Guarana in Caenorhabditis elegans. Nutrients 2022, 14, 1986. https://
dc.description.abstractGuarana (Paullinia cupana) is a widely consumed nutraceutical with various health benefits supported by scientific evidence. However, its indirect health impacts through the gut microbiota have not been studied. Caenorhabditis elegans is a useful model to study both the direct and indirect effects of nutraceuticals, as the intimate association of the worm with the metabolites produced by Escherichia coli is a prototypic simplified model of our gut microbiota. We prepared an ethanoic extract of guarana seeds and assessed its antioxidant capacity in vitro, with a 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, and in vivo, utilizing C. elegans. Additionally, we studied the impact of this extract on C. elegans lifespan, utilizing both viable and non-viable E. coli, and assessed the impact of guarana on E. coli folate production. The extract showed high antioxidant capacity, and it extended worm lifespan. However, the antioxidant and life-extending effects did not correlate in terms of the extract concentration. The extract-induced life extension was also less significant when utilizing dead E. coli, which may indicate that the effects of guarana on the worms work partly through modifications on E. coli metabolism. Following this observation, guarana was found to decrease E. coli folate production, revealing one possible route for its beneficial effects.en_US
dc.format.extent15 p.en_US
dc.relationThis research was funded by an Academy of Finland grant 333291 to LH and open access funding provided by University of Helsinkien_US
dc.rightsAtribución 4.0 Internacional*
dc.subjectPaullinia cupanaen_US
dc.subjectEscherichia colien_US
dc.subjectDietary supplementen_US
dc.subjectInflammatory bowel diseaseen_US
dc.titleAlterations in Bacterial Metabolism Contribute to the Lifespan Extension Exerted by Guarana in Caenorhabditis elegansen_US
dc.typejournal articlees_ES
dc.rights.accessRightsopen accesses_ES
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