Please use this identifier to cite or link to this item: https://repositorio.usj.es/handle/123456789/792

Title: The Potential Role of Everlasting Flower (Helichrysum stoechas Moench) as an Antihypertensive Agent: Vasorelaxant Effects in the Rat Aorta
Authors: Valero Gracia, Marta Sofía ORCID SCOPUSID
Nuñez Alonso, Sonia ORCID
Les Parellada, Francisco ORCID SCOPUSID
Castro, Marta ORCID RESEARCHERID SCOPUSID
Gómez-Rincón, Carlota ORCID SCOPUSID
Arruebo, María Pilar ORCID RESEARCHERID SCOPUSID
Plaza, Miguel Ángel ORCID RESEARCHERID
Köhler, Ralf ORCID SCOPUSID
López Ramos, Víctor ORCID SCOPUSID
Keywords: Antioxidants; Calcium channels; Hypertension; Medicinal plants; NOS; Polyphenols
Issue Date: 31-May-2022
Publisher: MDPI
Citation: Valero, M.S.; Nuñez, S.; Les, F.; Castro, M.; Gómez-Rincón, C.; Arruebo, M.P.; Plaza, M.Á.; Köhler, R.; López, V. The Potential Role of Everlasting Flower (Helichrysum stoechas Moench) as an Antihypertensive Agent: Vasorelaxant Effects in the Rat Aorta. Antioxidants 2022, 11, 1092. https://doi.org/10.3390/antiox11061092
Abstract: Helichrysum stoechas (L.) Moench (H. stoechas) is a medicinal plant traditionally used in the Iberian Peninsula to treat different disorders such as arterial hypertension. The aim of this study was to investigate the vascular effects of a polyphenolic methanolic extract of H. stoechas, which has high antioxidant activity, and its mechanism of action. Isometric myography studies were performed in an organ bath with rat aortic rings with intact endothelium. The H. stoechas extract produced vasorelaxation in the aortic rings that were precontracted by phenylephrine or KCl. L-NAME and Rp-8-Br-PET-cGMPS but not indomethacin or H-89; it also reduced the relaxant response evoked by H. stoechas extract on the phenylephrine-induced contractions. H. stoechas extract reduced the response to CaCl2 similar to verapamil and reduced the phenylephrine-induced contractions comparable with heparin. TRAM-34, apamin and glibenclamide reduced relaxation induced by the H. stoechas extract. The combination of L-NAME+TRAM-34+apamin almost completely inhibited the H. stoechas-induced effect. In conclusion, the relaxant effect of the H. stoechas extract is partially mediated by endothelium through the activation of the NO/PKG/cGMP pathway and the opening of Ca2+-activated K+ channels. Furthermore, the decrease in the cytosolic Ca2+ by the inhibition of Ca2+ influx through the L-type Ca2+ channels and by the reduction of Ca2+ release from the sarcoplasmic reticulum via the IP3 pathway is also involved.
URI: https://repositorio.usj.es/handle/123456789/792
ISSN: 2076-3921
Appears in Collections:Artículos de revistas

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