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dc.contributor.authorCásedas, Guillermo-
dc.contributor.authorLes, Francisco-
dc.contributor.authorGonzález-Burgos, Elena-
dc.contributor.authorGómez-Serranillos, M. Pilar-
dc.contributor.authorSmith, Carine-
dc.contributor.authorLópez Ramos, Víctor-
dc.date.accessioned2021-02-18T09:45:45Z-
dc.date.available2021-02-18T09:45:45Z-
dc.date.issued2018-07-17-
dc.identifier.citationCásedas, G., Les, F., González-Burgos, E., Gómez-Serranillos, M.P., Smith, C., López, V., 2019. Cyanidin-3-O-glucoside inhibits different enzymes involved in central nervous system pathologies and type-2 diabetes. South African Journal of Botany 120, 241–246.. doi:10.1016/j.sajb.2018.07.001es_ES
dc.identifier.issn0254-6299es_ES
dc.identifier.urihttps://repositorio.usj.es/handle/123456789/483-
dc.description.abstractCyanidin-3-O-glucoside, also known as kuromanin, is one of the most important anthocyanins in nature. Thescope of this paper is to discuss the potential role of this anthocyanin as therapeutic agent to prevent or treatchronic diseases in which oxidative stress may be involved through a modulation of certain enzymes. The inhib-itory potential of cyanidin-3-O-glucoside against enzymatic targets of neurodegenerative or metabolic diseaseswas tested using monoamine oxidase A (MAO-A), acetylcholinesterase (AChE), tyrosinase (TYR), fatty acidamide hydrolase (FAAH),α-glucosidase (α-GLU) and dipeptidyl peptidase-4 (DPP-4). The antioxidant activitywas evaluated through the xanthine/xanthine oxidase system. Cyanidin-3-O-glucoside inhibited MAO-A,TYR and FAAH enzymes whereas it could not inhibit AChE activity. IC50values for these assays were 7.6μM,18.1μM and 152.1μM, respectively. Additionally, cyanidin-3-O-glucoside was able to inhibitα-GLU (IC50=479.8μM) and DPP-4 (IC50= 125.1μM). Finally, the antioxidant activity of cyanidin-3-O-glucoside was con-firmedby the xanthine/xanthine oxidase method, being more efficient than gallicacidassuperoxide radicalscav-enger. In conclusion, cyanidin-3-O-glucoside has demonstrated to be a candidate as enzyme inhibitor withneuroprotective, antioxidant and antidiabetic potentiales_ES
dc.format.mimetypeapplication/pdfes_ES
dc.language.isoenges_ES
dc.publisherElsevier B.V.es_ES
dc.relationThis work was financially supported by Universidad San Jorge .es_ES
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectKuromanines_ES
dc.subjectAnthocyaninses_ES
dc.subjectCyanidin-3-O-glucosidees_ES
dc.subjectType-2 diabeteses_ES
dc.subjectNeurodegenerative diseaseses_ES
dc.subjectDietary polyphenolses_ES
dc.titleCyanidin-3-O-glucoside inhibits different enzymes involved in centralnervous system pathologies and type-2 diabeteses_ES
dc.typejournal articlees_ES
dc.identifier.publicationfirstpage241es_ES
dc.identifier.publicationlastpage246es_ES
dc.identifier.doi10.1016/j.sajb.2018.07.001es_ES
dc.rights.accessRightsopen accesses_ES
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