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dc.contributor.authorMonasterio, Violeta-
dc.contributor.authorCarro, Jesús-
dc.contributor.authorPueyo, Esther-
dc.contributor.authorRodríguez, José F.-
dc.date.accessioned2021-03-03T09:47:26Z-
dc.date.available2021-03-03T09:47:26Z-
dc.date.issued2015-09-
dc.identifier.citationV. Monasterio, J. Carro, E. Pueyo and J. F. Rodríguez, "The role of purkinje automaticity as an arrhythmia mechanism in hyperkalaemia," 2015 Computing in Cardiology Conference (CinC), Nice, France, 2015, pp. 873-876, doi: 10.1109/CIC.2015.7411050.es_ES
dc.identifier.isbn978-1-5090-0685-4es_ES
dc.identifier.urihttps://repositorio.usj.es/handle/123456789/515-
dc.descriptionColección: Computing in Cardiology Conferencees_ES
dc.description.abstractThe pacemaker activity of Purkinje (PK) cells is usually suppressed by the sino-atrial (SA) node. Under abnormal conditions, PK cells may produce ectopic focal activity leading to tachycardia and fibrillation. This computational modelling work illustrates the potential role of PK automaticity as an arrhythmia mechanism in hyperkalaemia. First, we investigated the automaticity of isolated PK cells under hyperkalaemic conditions. Second, the potential consequences of altered PK automaticity were explored in a 1-D model of a terminal PK fibre running through a hyperkalaemic zone. Hyperkalaemia was found to accelerate the autorhythmic period of isolated PK cells with respect to control. For extracellular potassium levels >= 7.2 mM, spontaneous action potentials (APs) appeared in the PK fibre, leading to conduction disturbances and complex combinations of spontaneous and stimulation-driven APs.es_ES
dc.format.mimetypeapplication/pdfes_ES
dc.language.isoenges_ES
dc.publisherIEEE, 345 E 47TH ST, NEW YORK, NY 10017 USAes_ES
dc.relation.requiresAdobe PDFes_ES
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectIschemiaes_ES
dc.titleThe Role of Purkinje Automaticity as an Arrhythmia Mechanism in Hyperkalaemiaes_ES
dc.typeinfo:eu-repo/semantics/conferenceObjectes_ES
dc.relation.publisherversionhttps://ieeexplore.ieee.org/document/7411050es_ES
dc.identifier.publicationfirstpage873es_ES
dc.identifier.publicationlastpage876es_ES
dc.identifier.doi10.1109/CIC.2015.7411050es_ES
dc.identifier.publicationtitleComputing in Cardiology 2015 volume 42 : September 6-9, 2015, Nice, Francees_ES
dc.relation.eventdate2015-09-06-
dc.relation.eventplaceComp in Cardiol 2015, nice, FRANCEes_ES
dc.relation.eventtitle2015 Comp in Cardiol Conference (CinC)es_ES
dc.rights.accessrightsinfo:eu-repo/semantics/openAccesses_ES
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