Please use this identifier to cite or link to this item: https://repositorio.usj.es/handle/123456789/777

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dc.contributor.authorLópez Ramos, Víctor-
dc.contributor.authorMustafa, Ahmed M.-
dc.contributor.authorAbouelenein, Doaa-
dc.contributor.authorMazzara, Eugenia-
dc.contributor.authorAngeloni, Simone-
dc.contributor.authorNuñez Alonso, Sonia-
dc.contributor.authorSagratini, Gianni-
dc.contributor.authorCespi, Marco-
dc.contributor.authorVittori, Sauro-
dc.contributor.authorCaprioli, Giovanni-
dc.contributor.authorMaggi, Filippo-
dc.date.accessioned2022-05-10T13:23:38Z-
dc.date.available2022-05-10T13:23:38Z-
dc.date.issued2022-01-14-
dc.identifier.citationMustafa, A.M.; Mazzara, E.; Abouelenein, D.; Angeloni, S.; Nunez, S.; Sagratini, G.; López, V.; Cespi, M.; Vittori, S.; Caprioli, G.; et al. Optimization of Solvent-Free Microwave-Assisted Hydrodiffusion and Gravity Extraction of Morus nigra L. Fruits Maximizing Polyphenols, Sugar Content, and Biological Activities Using Central Composite Design. Pharmaceuticals 2022, 15, 99. https://doi.org/10.3390/ph15010099es_ES
dc.identifier.urihttps://repositorio.usj.es/handle/123456789/777-
dc.description.abstractBlack mulberry, Morus nigra L. (family: Moraceae), is a healthy food and medicinal plant. Microwave hydrodiffusion and gravity (MHG) is one of the most innovative applications of solventfree microwave extraction. The aim of this study was to optimize for the first time the MHG solventfree extraction of polyphenols and sugars from M. nigra fruits. Optimization was carried out using a central composite design (CCD) with selected responses such as extraction yield, total polyphenol (TPC), flavonoid (TFC), anthocyanin (TAC), and sugar (TSC) contents, in addition to DPPH radical scavenging, and -glucosidase (AGHi), lipase (Li), and xanthine oxidase (XOi) inhibition as tools to evaluate the best parameters for efficient and rapid extraction of black mulberry. The optimized extract was characterized in terms of the aforementioned parameters to validate the models, and was further analyzed for 36 individual polyphenols using HPLC-MS/MS. The optimized MHG extract was finally compared with traditional extracts, and demonstrated much better performance in terms of TPC, TAC, and Li, while the traditional extracts showed better XOi and AGHi. In conclusion, MHG is a valuable green technique for the production of non-degraded black mulberry polyphenol-rich extract and we suggest its larger use in the pharmaceutical and food industries.es_ES
dc.format.mimetypeapplication/pdfes_ES
dc.language.isoenges_ES
dc.publishermdpies_ES
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectMorus nigraes_ES
dc.subjectmicrowave hydrodiffusion and gravityes_ES
dc.subjectpolyphenolses_ES
dc.subjectsugar contentes_ES
dc.subjecta- glucosidasees_ES
dc.subjectlipasees_ES
dc.subjectxanthine oxidasees_ES
dc.subjectDPPH radical scavenginges_ES
dc.subjectcentral composite designes_ES
dc.titleOptimization of Solvent-Free Microwave-Assisted Hydrodiffusion and Gravity Extraction of Morus nigra L. Fruits Maximizing Polyphenols, Sugar Content, and Biological Activities Using Central Composite Designes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.identifier.doihttps://doi.org/10.3390/ph15010099es_ES
dc.rights.accessrightsinfo:eu-repo/semantics/openAccesses_ES
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