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Título : Developmental origins of Parkinson disease: Improving the rodent models
Autor: Jiménez-Salvador, Irene RESEARCHERID SCOPUSID
Meade, Patricia ORCID RESEARCHERID SCOPUSID
Iglesias, Eldris ORCID SCOPUSID
Bayona-Bafaluy, Pilar ORCID SCOPUSID
Ruiz-Pesini, Eduardo ORCID SCOPUSID
Palabras clave : Parkinson disease; Developmental origins; Pesticide; Oxidative phosphorylation; Rodent model
Fecha de publicación: 10-feb-2023
Editorial : Elsevier
Citación : Irene Jiménez-Salvador, Patricia Meade, Eldris Iglesias, Pilar Bayona-Bafaluy, Eduardo Ruiz-Pesini, Developmental origins of Parkinson disease: Improving the rodent models,Ageing Research Reviews, Volume 86, 2023, 101880, ISSN 1568-1637,https://doi.org/10.1016/j.arr.2023.101880.
Resumen : Numerous pesticides are inhibitors of the oxidative phosphorylation system. Oxidative phosphorylation dysfunction adversely affects neurogenesis and often accompanies Parkinson disease. Since brain development occurs mainly in the prenatal period, early exposure to pesticides could alter the development of the nervous system and increase the risk of Parkinson disease. Different rodent models have been used to confirm this hypothesis. However, more precise considerations of the selected strain, the xenobiotic, its mode of administration, and the timing of animal analysis, are necessary to resemble the model to the human clinical condition and obtain more reliable results.
URI : https://repositorio.usj.es/handle/123456789/1046
ISSN : 1568-1637
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