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https://repositorio.usj.es/handle/123456789/1061
Title: | Assessment of ventricular repolarization instability in terms of T-wave alternans induced by head-down bed-rest immobilization ( Author submitted manuscript) |
Authors: | Monasterio, Violeta
Martín-Yebra, Alba Landreani, Federica Laguna, Pablo Martinez, Juan Pablo Caiani, Enrico G. |
Keywords: | Microgravity; Head-down bed-rest (HDBR); Ventricular repvolarization; Electrocardiogram (ECG); T wave alternans (TWA); Cardiac arrhythmias |
Issue Date: | 2019 |
Publisher: | IOP Publishing |
Citation: | Alba Martín-Yebra et al 2019 Physiol. Meas. 40 104001 |
Abstract: | Objective: To assess the effects of different durations of simulated microgravity exposure on ventricular repolarization (VR) in terms of T-wave alternans (TWA) as well as to test whether an increase in VR heterogeneity could be detected once normal gravity was restored. Approach: A total of 63 healthy volunteers were recruited in several head-down bed-rest (HDBR) experiments in the context of the European Space Agency bed-rest strategy. TWA is evaluated during the night period using ambulatory ECG recordings, before, during and after long- (60 d), mid- (21 d) and short- (5 d) duration HDBR by the long-term averaging technique. Main results: 5-21 d of exposure to simulated microgravity by means of the HDBR model do not lead to a significant increase of cardiac electrical instability in healthy myocardial substrates up to the point of eliciting TWA on the surface ECG. However, TWA indices increased after long-term HDBR exposure, once normal gravity was re-established, indicative of incipient electrical instability on VR at the conclusion of 60 d of HDBR. Significance: The results of this work underline the importance of focusing future research on immediate effects after long-term microgravity exposure, both simulated by HDBR or from space mission scenarios, once partial gravity conditions are re-established. A deeper insight in the understanding of human body reactions in these scenarios results crucial in the design of future long-duration spaceflight missions, to mitigate any potential risk that can limit astronaut's performance. |
URI: | https://repositorio.usj.es/handle/123456789/1061 |
ISSN: | 0967-3334 |
Appears in Collections: | Artículos de revistas |
Files in This Item:
File | Description | Size | Format | |
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Assessment of ventricular repolarization instability.pdf | 1,21 MB | Adobe PDF | View/Open |
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