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Title: Impact of eight widely consumed antibiotics on the growth and physiological profile of natural soil microbial communities (Manuscript Draft)
Authors: Pino Otín, Rosa ORCID SCOPUSID
Ballestero Fernández, Diego
Langa Morales, Elisa SCOPUSID
Roig, Francisco J. ORCID SCOPUSID
Terrado, Eva María SCOPUSID
Keywords: Microorganisms; Soil ecotoxty; Biolog EcoPlates
Issue Date: Oct-2022
Publisher: Elsevier
Citation: María Rosa Pino-Otín, Natalia Ferrando, Diego Ballestero, Elisa Langa, Francisco J. Roig, Eva M. Terrado, Impact of eight widely consumed antibiotics on the growth and physiological profile of natural soil microbial communities, Chemosphere,Volume 305,2022,135473,ISSN 0045-6535,
Abstract: Antibiotics’ (ATBs) occurrence in soil ecosystems has a relevant effect in the structure and functionality of edaphic microbial communities, mainly because of their amendment with manure and biosolids that alter their key ecological functions. In this study, the impact of eight widely consumed ATBs on a natural soil microbial community, characterized through 16S rRNA gene sequencing, was evaluated. Changes induced by the ATBs in the growth of the soil microbiota and in the community-level physiological profiling (CLPP), using Biolog EcoPlatesTM, were measured as endpoint. The eight assayed ATBs lead to a significant decrease in the growth of soil microbial communities in a dose-dependent way, ordered by its effect as follows: chloramphenicol > gentamycin > erythromycin > ampicillin > penicillin > amoxicillin > tetracycline > streptomycin. Chloramphenicol, gentamycin, and erythromycin adversely affected the physiological profile of the soil community, especially its ability to metabolize amino acids, carboxylic and ketonic acids and polymers. The analysis of the relationship between the physico-chemical properties of ATBs, as well as their mechanism of action, revealed that, except for the aminoglycosides, each ATB is influenced by a different physico-chemical parameters, even for ATBs of the same family. Significant effects were detected from 100 μg mL-1, concentrations that can be found in digested sludge, biosolids and even in fertilized soils after repeated application of manure, so cumulative and long-term effects of these antibiotics on soil environment cannot be ruled out.
ISSN: 0045-6535
Appears in Collections:Artículos de revistas

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