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Title: Lipid lowering and anti-ageing effects of edible flowers of Viola x wittrockiana Gams in a Caenorhabditis elegans obese model (Metadatos)
Authors: Núñez Alonso, Sonia ORCID
López Ramos, Víctor ORCID SCOPUSID
Gómez-Rincón, Carlota ORCID SCOPUSID
Issue Date: 2-Oct-2023
Publisher: Royal Society of Chemistry
Citation: Nuñez Alonso, Sonia & Lopez, Victor & Moliner, Cristina & Valero, Marta & Gómez, Carlota. (2023). Lipid lowering and anti-ageing effects of edible flowers of Viola x wittrockiana Gams in Caenorhabditis elegans obese model. Food & Function. 14. 10.1039/D3FO02181E.
Abstract: Life expectancy has increased considerably in the last decades, clearing the way for preventive medicine. The ingestion of healthy foods or ingredients to improve health is gaining attention and edible flowers entail a promising source of bioactive compounds. The aim of this work was to study the anti-ageing and anti-obesity properties of an extract obtained from an edible flower Viola x wittrockiana though in vitro and in vivo methodologies with Caenorhabditis elegans as a model. The capacity to inhibit the enzymes α-glucosidase and lipase as well as to prevent advance glycation end-product (AGE) formation was tested in vitro. Caenorhabditis elegans was used as an obesity in vivo model to assess the effects of the extract on fat accumulation, development, progeny and health span. Viola flowers showed lower IC50 values in the α-glucosidase assay than the reference drug acarbose and exerted a higher inhibition of AGE formation than the reference substance aminoguanidine; the extract also showed pancreatic lipase inhibiting properties. Moreover, the extract lowered fat storage of C. elegans in a dose-dependent manner, up to 90.37% at the highest tested dose, and improved health span biomarkers such as lipofuscin accumulation and progeny availability. Our results demonstrate, for the first time, the anti-obesogenic and anti-ageing activity of Viola x wittrockiana flowers and their potential use as functional foods and nutraceuticals.
ISSN: 2042-650X
Appears in Collections:Artículos de revistas

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