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dc.contributor.authorOlivan-Viguera, Aida-
dc.contributor.authorGarcía-Otín, Ángel Luis-
dc.contributor.authorLozano-Gerona, Javier-
dc.contributor.authorAbarca-Lachén, Edgar-
dc.contributor.authorGarcía-Malinis, Ana J.-
dc.contributor.authorGilaberte, Yolanda-
dc.contributor.authorPueyo, Esther-
dc.contributor.authorKöhler, Ralf-
dc.date.accessioned2019-12-05T13:00:02Z-
dc.date.available2019-12-05T13:00:02Z-
dc.date.issued2018-01-02-
dc.identifier.citationOlivan-Viguera A, Garcia-Otin AL, Lozano-Gerona J, Abarca-Lachen E, Garcia-Malinis AJ, Hamilton KL, et al. (2018) Pharmacological activation of TRPV4 produces immediate cell damage and induction of apoptosis in human melanoma cells and HaCaT keratinocytes. PLoS ONE 13(1): e0190307. https://doi.org/10.1371/journal.pone.0190307es_ES
dc.identifier.issn1932-6203es_ES
dc.identifier.urihttps://repositorio.usj.es/handle/123456789/248-
dc.description.abstractTRPV4 channels are calcium-permeable cation channels that are activated by several physicochemical stimuli. Accordingly, TRPV4 channels have been implicated in the regulation of osmosensing, mechanotransduction, thermosensation, and epithelial/endothelial barrier functions. Whether TRPV4 is also mechanistically implicated in melanoma cell proliferation is not clear. Here, we hypothesized that TRPV4 is expressed in human melanoma and that pharmacological activation interferes with cell proliferation.es_ES
dc.format.extent19 p.es_ES
dc.format.mimetypeapplication/pdfes_ES
dc.language.isoenges_ES
dc.publisherAndrzej T. Slominski, University of Alabama at Birmingham, UNITED STATESes_ES
dc.relation.requiresAdobe PDFes_ES
dc.rightsAtribución 4.0 Internacional*
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectTRPV4es_ES
dc.subjectCélulases_ES
dc.subjectMelanoma humanoes_ES
dc.subjectQueratinocitoses_ES
dc.subjectHaCaTes_ES
dc.titlePharmacological activation of TRPV4 produces immediate cell damage and induction of apoptosis in human melanoma cells and HaCaT keratinocyteses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.subject.unescoBiología celulares_ES
dc.relation.publisherversionhttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0190307es_ES
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0190307es_ES
dc.rights.accessrightsinfo:eu-repo/semantics/openAccesses_ES
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