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| Title: | Pharmacological activation of TRPV4 produces immediate cell damage and induction of apoptosis in human melanoma cells and HaCaT keratinocytes |
| Authors: | Olivan-Viguera, Aida
García-Otín, Ángel Luis
Lozano-Gerona, Javier
Abarca-Lachén, Edgar
García-Malinis, Ana J.
Gilaberte, Yolanda
Pueyo, Esther
Köhler, Ralf
|
| Keywords: | TRPV4; Células; Melanoma humano; Queratinocitos; HaCaT |
| Issue Date: | 2-Jan-2018 |
| Publisher: | Andrzej T. Slominski, University of Alabama at Birmingham, UNITED STATES |
| Citation: | Olivan-Viguera A, Garcia-Otin AL, Lozano-Gerona J, Abarca-Lachen E, Garcia-Malinis AJ, Hamilton KL, et al. (2018) Pharmacological activation of TRPV4 produces immediate cell damage and induction of apoptosis in human melanoma cells and HaCaT keratinocytes. PLoS ONE 13(1): e0190307. https://doi.org/10.1371/journal.pone.0190307 |
| Abstract: | TRPV4 channels are calcium-permeable cation channels that are activated by several physicochemical stimuli. Accordingly, TRPV4 channels have been implicated in the regulation of osmosensing, mechanotransduction, thermosensation, and epithelial/endothelial barrier functions. Whether TRPV4 is also mechanistically implicated in melanoma cell proliferation is not clear. Here, we hypothesized that TRPV4 is expressed in human melanoma and that pharmacological activation interferes with cell proliferation. |
| URI: | https://repositorio.usj.es/handle/123456789/248 |
| ISSN: | 1932-6203 |
| Appears in Collections: | Artículos de revistas |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| journal.pone.0190307.pdf | 20,18 MB | Adobe PDF |  View/Open |
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