Please use this identifier to cite or link to this item: https://repositorio.usj.es/handle/123456789/637

Full metadata record
DC FieldValueLanguage
dc.contributor.authorYousefi-Manesh, Hasan-
dc.contributor.authorDehpour, A. R.-
dc.contributor.authorShirooie, Samira-
dc.contributor.authorBagheri, Fariba-
dc.contributor.authorFarrokhi, Vida-
dc.contributor.authorMousavi, Seyyedeh Elaheh-
dc.contributor.authorRicciutelli, Massimo-
dc.contributor.authorCappellacci, Loredana-
dc.contributor.authorLópez Ramos, Víctor-
dc.contributor.authorMaggi, Filippo-
dc.contributor.authorPetrelli, Riccardo-
dc.date.accessioned2021-10-25T07:38:40Z-
dc.date.available2021-10-25T07:38:40Z-
dc.date.issued2021-04-09-
dc.identifier.citationYousefi-Manesh, H.; Dehpour, A.R.; Shirooie, S.; Bagheri, F.; Farrokhi, V.; Mousavi, S.E.; Ricciutelli, M.; Cappellacci, L.; López, V.; Maggi, F.; et al. Isofuranodiene, a Natural Sesquiterpene Isolated from Wild Celery (Smyrnium olusatrum L.), Protects Rats against Acute Ischemic Stroke. Pharmaceuticals 2021, 14, 344. https://doi.org/10.3390/ph14040344es_ES
dc.identifier.issn1424-8247es_ES
dc.identifier.urihttps://repositorio.usj.es/handle/123456789/637-
dc.description.abstractThe myrrh-like furanosesquiterpene isofuranodiene (IFD) is the main constituent of wild celery (Smyrnium olusatrum L., Apiaceae), an overlooked vegetable that was cultivated during the Roman Empire. In the present study, we investigated the protective effects of IFD pre-treatment against oxidative stress and inflammatory response in an animal model of ischemic stroke. IFD was isolated by the crystallization of Smyrnium olusatrum essential oil, and its structure and purity were confirmed by NMR and HPLC analyses. Acute pre-treatment of IFD (10 mg/kg i.p.) significantly reduced the levels of the inflammatory cytokines IL-1 beta and TNF-alpha, the expression of pNF-kappa B/NF-kappa B, and the lipid peroxidation indicator MDA. Finally, IFD boosted a faster recovery and better scores in grid-walking and modified neurological severity scores (mNSS) tests. Taken together, these findings indicate IFD as a promising lead compound for the discovery of new treatments of brain ischemia.es_ES
dc.format.extent9es_ES
dc.format.mimetypeapplication/pdfes_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.relationThis study has been supported by the Tehran University of Medical Sciences (TUMS) and a grant from the Italian Ministry of Health to R.P. (PRIN 2017CBNCYT_005).es_ES
dc.relation.requiresAdobees_ES
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectIsofuranodienees_ES
dc.subjectSmyrnium olusatrum L.es_ES
dc.subjectIschemic strokees_ES
dc.subjectNF-kBes_ES
dc.subjectIL-1 betaes_ES
dc.subjectTNF-alphaes_ES
dc.titleIsofuranodiene, a Natural Sesquiterpene Isolated from Wild Celery (Smyrnium olusatrum L.), Protects Rats against Acute Ischemic Strokees_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttps://www.mdpi.com/1424-8247/14/4/344es_ES
dc.identifier.publicationfirstpage1es_ES
dc.identifier.publicationlastpage9es_ES
dc.identifier.doi10.3390/ph14040344es_ES
dc.rights.accessrightsinfo:eu-repo/semantics/openAccesses_ES
Appears in Collections:Artículos de revistas



This item is licensed under a Creative Commons License Creative Commons