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https://repositorio.usj.es/handle/123456789/888
Título : | Atrial fibrosis identification with unipolar electrogram eigenvalue distribution analysis in multi‑electrode arrays |
Autor: | Riccio, Jennifer
Alcaine Otín, Alejandro Rocher, Sara Martinez-Mateu, Laura Laguna, Pablo Martinez, Juan Pablo Laguna, Pablo Saiz, Javier Guillem, Maria S Invers‑Rubio, Eric |
Palabras clave : | Atrial fibrosis; Atrial fibrillation (AF); Bipolar electrograms (b-EGMs); Eigenvalue dominance ratio (EIGDR); Unipolar electrograms (u-EGMs) |
Fecha de publicación: | 13-sep-2022 |
Editorial : | Springer |
Resumen : | Atrial fibrosis plays a key role in the initiation and progression of atrial fibrillation (AF). Atrial fibrosis is typically identified by a peak-to-peak amplitude of bipolar electrograms (b-EGMs) lower than 0.5 mV, which may be considered as ablation targets. Nevertheless, this approach disregards signal spatiotemporal information and b-EGM sensitivity to catheter orientation. To overcome these limitations, we propose the dominant-to-remaining eigenvalue dominance ratio (EIGDR) of unipolar electrograms (u-EGMs) within neighbor electrode cliques as a waveform dispersion measure, hypothesizing that it is correlated with the presence of fibrosis. A simulated 2D tissue with a fibrosis patch was used for validation. We computed EIGDR maps from both original and time-aligned u-EGMs, denoted as R and RA , respectively, also mapping the gain in eigenvalue concentration obtained by the alignment, ΔRA . The performance of each map in detecting fibrosis was evaluated in scenarios including noise and variable electrode-tissue distance. Best results were achieved by RA , reaching 94% detection accuracy, versus the 86% of b-EGMs voltage maps. The proposed strategy was also tested in real u-EGMs from fibrotic and non-fibrotic areas over 3D electroanatomical maps, supporting the ability of the EIGDRs as fibrosis markers, encouraging further studies to confirm their translation to clinical settings |
URI : | https://repositorio.usj.es/handle/123456789/888 |
ISSN : | 3091–3112 |
Aparece en las colecciones: | Artículos de revistas |
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Atrial fibrosis identification.pdf | 4 MB | Adobe PDF | Visualizar/Abrir |
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