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Title: Isofuranodiene, a Natural Sesquiterpene Isolated from Wild Celery (Smyrnium olusatrum L.), Protects Rats against Acute Ischemic Stroke
Authors: Yousefi-Manesh, Hasan SCOPUSID
Shirooie, Samira SCOPUSID
Bagheri, Fariba SCOPUSID
Farrokhi, Vida SCOPUSID
Mousavi, Seyyedeh Elaheh SCOPUSID
Ricciutelli, Massimo SCOPUSID
Cappellacci, Loredana ORCID SCOPUSID
López Ramos, Víctor ORCID SCOPUSID
Maggi, Filippo ORCID
Petrelli, Riccardo ORCID SCOPUSID
Keywords: Isofuranodiene; Smyrnium olusatrum L.; Ischemic stroke; NF-kB; IL-1 beta; TNF-alpha
Issue Date: 9-Apr-2021
Publisher: MDPI
Citation: Yousefi-Manesh, H.; Dehpour, A.R.; Shirooie, S.; Bagheri, F.; Farrokhi, V.; Mousavi, S.E.; Ricciutelli, M.; Cappellacci, L.; López, V.; Maggi, F.; et al. Isofuranodiene, a Natural Sesquiterpene Isolated from Wild Celery (Smyrnium olusatrum L.), Protects Rats against Acute Ischemic Stroke. Pharmaceuticals 2021, 14, 344.
Abstract: The myrrh-like furanosesquiterpene isofuranodiene (IFD) is the main constituent of wild celery (Smyrnium olusatrum L., Apiaceae), an overlooked vegetable that was cultivated during the Roman Empire. In the present study, we investigated the protective effects of IFD pre-treatment against oxidative stress and inflammatory response in an animal model of ischemic stroke. IFD was isolated by the crystallization of Smyrnium olusatrum essential oil, and its structure and purity were confirmed by NMR and HPLC analyses. Acute pre-treatment of IFD (10 mg/kg i.p.) significantly reduced the levels of the inflammatory cytokines IL-1 beta and TNF-alpha, the expression of pNF-kappa B/NF-kappa B, and the lipid peroxidation indicator MDA. Finally, IFD boosted a faster recovery and better scores in grid-walking and modified neurological severity scores (mNSS) tests. Taken together, these findings indicate IFD as a promising lead compound for the discovery of new treatments of brain ischemia.
ISSN: 1424-8247
Appears in Collections:Artículos de revistas

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